The life-saving pills are actually something that severely tests a ruler's self-restraint. Ruthless tyrants and fanatics would mostly ignore their dangers, using them as weapons for conquest. Idealists would abhor them, as the destruction of moral order and ethical norms is always unacceptable to conservatives.
The fact that Tsunade and Mizuki treated them as a strategic resource was not a mistake at all. The massive costs of production and use heavily restricted Mizuki's ability to mass-produce them. Only an organization as powerful as a Ninja Village at the peak of the ninja world could fully unlock the potential of the life-saving pills. Of course, their risks would also become much more apparent.
Seeing Mizuki confirm her suspicions, Tsunade showed no particular reaction. Calmly, she asked, "Developing this kind of pill surely couldn't have been accomplished overnight, right? Although various chakra-draining techniques and secret medicinal formulas keep emerging, a pill with such extreme effects as yours—capable even of creating a complete clone—is definitely not easy to produce."
Mizuki replied, "My original intention was simply to create a potent healing agent. It was only later I realized its tremendous value in medical research."
Mizuki wasn't lying here. Initially, it really was intended merely as a treatment drug with serious side effects, but he later accidentally discovered how sensitive the pill was to chakra, offering unparalleled advantages in cellular replication while effectively suppressing random mutations. At that point, its value became far more than just a simple healing potion.
"Since you understand all this so clearly, I suppose you've conducted quite a few private experiments yourself? Your sudden increase in strength over these past few months should probably be credited to this pill as well. No one understands how to use this pill better than its own inventor..."
Faced with Tsunade's question, Mizuki hesitated slightly before finally admitting, "While not directly related, it indeed helped me immensely. Without this pill, I wouldn't have advanced this smoothly. Therefore, yes, there have been some secret human trials—I won't deny it. But I never intentionally harmed anyone specifically for experimentation."
Aside from Tsubaki and his own samples, the rest came from battle trophies or remains left after fights—never obtained recklessly like Orochimaru ever did.
"You don't have to worry. I already know exactly what happened with your human trials."
Ever since learning about the effects of the life-saving pills, Tsunade had already begun secretly investigating Mizuki's background. Many details even Mizuki himself hadn't noticed were thoroughly checked. Most importantly, they verified whether any civilians or low-ranking ninja in the village had gone missing without explanation in recent months. Fortunately, everything turned out fine.
"For someone like you with the life-saving pills, getting materials for human trials should never be as bloody or difficult as it was for Orochimaru. If I hadn't already known that you still had some sense of morality, what awaited you would've been a pursuit by Anbu."
"Thank you for your mercy!"
Mizuki bowed deeply in gratitude, speaking sincerely.
Don't bother thanking me. It's only because you haven't gone too far yet — otherwise, I wouldn't be holding back. Even the best swimmers sometimes drown. The finest riders can still fall. Watch your step.
Understood. I definitely won't cause you any trouble.
Tsunade nodded before continuing, "Has your way of making these pills gotten out?"
"No!" Mizuki shook his head. "The process is really complicated, so production stays low. Even I don't have much stock left. The formula itself is nearly impossible to understand."
Even Mizuki himself had relied on Chakra — that universal tool — using it in a rough and direct way to extract what he needed and synthesize the pills. Biology and medicine in this world were still incredibly basic. Don't even get started on advanced stuff like PCR or gene replication — not that Mizuki himself understood any of that either. In the ninja world, no one else stood a chance. The gap in technology was just too huge; science almost looked like jutsu. If he wanted mass production, Mizuki would have to teach the process the hard way — one-on-one, step-by-step. And the learning curve? Insanely steep. So far, even his own student, Sakura Haruno, hadn't come close to grasping the basics. Teaching ninjas — whose minds were built for throwing kunai and controlling Chakra — an entirely different field wasn't something you could just pull off.
"If the method is so difficult, have you considered the risk of someone figuring it out?"
"Figuring it out?" Mizuki hesitated briefly before replying with cautious composure. "I don't think it's likely, but in the ninja world, there's no such thing as completely impossible."
Take Jugo's Cursed Seal — its carrier was a special kind of enzyme created through a Kekkei Genkai. If Orochimaru could figure it out, copy it, and make it his own, then reverse-engineering the Omnipotence Pill wasn't totally unthinkable either. Still, without any leads, the chances remained slim.
"I see. Got it!"
Tsunade herself had actually tried replicating the pill-making technique before. As Mizuki had said, with Chakra's help, it might just be possible. Using her extraordinary ability to control Chakra at the cellular level, she'd even managed to produce some samples identical in effect. But the efficiency was laughably low — like trying to grind an iron rod into a needle by hand when power tools were right there, ready to use.
"I've classified this as a restricted substance and already begun recovery operations. All previously distributed pills have been sealed away. So from now on, I expect you to shut down every source on your end. Unless personally authorized by me, I don't want these life-saving pills showing up anywhere again."
Alright.
Of the pills Mizuki originally handed out, aside from those already used, most had already been retrieved through various means. Any leftovers hiding somewhere would be negligible — not even enough for experiments, so nothing to worry about.
That settles this matter. But think carefully about the long-term consequences of this jutsu. There's no doubt about its value — we can't afford to throw it away. But its use must be tightly controlled. I'm sure you realize how dangerous your position is right now.
Mizuki knew this all too well. History has shown that those with powerful abilities often become targets themselves. A distant example was the Uzumaki clan, while a more recent one was the annihilation of the Uchiha clan. The naive Shisui Uchiha had revealed his ultimate genjutsu—Kotoamatsukami. It was only natural that any ambitious person would target him afterward.
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